Sail Central America from Atlantic to Pacific
View natural beauty and an engineering marvel across the Panama Canal
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Featured Panama Canal Cruises
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10 Night Panama Canal
Carnival Legend
Departing from: Galveston, TexasPorts of Call:- Cozumel, Mexico
- Puerto Limon, Costa Rica
- Colon, Panama
- Mahogany Bay (Roatan), Bay Islands, Honduras
Sailing Dates:- October 2025
- December 2025
- March 2026
interior from$984$98pernightoceanview from$1,214$121pernightbalcony from$1,609$161pernightsuite from$3,194$319pernightRewards & Bonus Offers:Interior from $984($98pernight)3.9 rating out of 5 (2,204 reviews) -
8 Night Panama Canal
Carnival Legend
Departing from: Tampa, FloridaPorts of Call:- Puerto Limon, Costa Rica
- Colon, Panama
- George Town, Grand Cayman
Sailing Dates:- January 2027
- March 2027
interior from$1,026$128pernightoceanview from$1,176$147pernightbalcony from$1,376$172pernightsuite from$2,218$277pernightInterior from $1,026($128pernight)3.9 rating out of 5 (2,204 reviews) -
16 Night Panama Canal Carnival Journeys - Eastbound
Carnival Spirit
Departing from: Seattle, WashingtonPorts of Call:- Cabo San Lucas, Mexico
- Puntarenas, Costa Rica
- Panama Canal Full Transit
- Cartagena, Colombia
- New Orleans, Louisiana
Sailing Dates:- October 2025
interior from$993$62pernightoceanview from$1,333$83pernightbalcony from$1,598$100pernightsuite fromCall for availabilityInterior from $993($62pernight)4 rating out of 5 (993 reviews) -
12 Night Panama Canal Discovery: Costa Rica & Greater Antilles
Rotterdam
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Relaxaway, Half Moon Cay, Bahamas (Cruiseline Private Island)
- Willemstad, Curacao
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- George Town, Grand Cayman
Sailing Dates:- October 2025
- December 2025
- February 2026
- March 2026
interior from$1,319$110pernightoceanview from$1,919$160pernightbalcony from$2,119$177pernightsuite from$3,219$268pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Earn 10 points per $1 spent
- Exclusive - Free $50 Shore Excursion Coupon
- Exclusive: Free Tamarind Dinner for 2 - Call
- Limited-Time: Kids Sail Free!
- Up to $500 to Spend on Board, Kids Sail Free & More
- Free Drinks, Dining, and Excursions with Select Fares
- Call for rates too low to show!
Interior from $1,319($110pernight)4.4 rating out of 5 (281 reviews) -
14 Night Panama Canal - Carnival Journeys
Carnival Venezia - Fun Italian Style!
Departing from: Port Canaveral (Orlando), FloridaPorts of Call:- Grand Turk Island, Turks & Caicos
- Oranjestad, Aruba
- Willemstad, Curacao
- Colon, Panama
- Puerto Limon, Costa Rica
- Montego Bay, Jamaica
- George Town, Grand Cayman
Sailing Dates:- January 2026
interior from$1,164$83pernightoceanview from$1,875$134pernightbalcony from$1,999$143pernightsuite fromCall for availabilityInterior from $1,164($83pernight)4.1 rating out of 5 (371 reviews) -
16 Night Panama Canal - Eastbound
Celebrity Summit
Departing from: San Pedro (Los Angeles), CaliforniaPorts of Call:- Puerto Vallarta, Mexico
- Puerto Quetzal, Guatemala
- Puntarenas, Costa Rica
- Panama Canal Full Transit
- Cartagena, Colombia
- Falmouth, Jamaica
- George Town, Grand Cayman
- Ft. Lauderdale (Port Everglades), Florida
Sailing Dates:- September 2025
interior from$1,377$86pernightoceanview from$1,617$101pernightbalcony from$2,842$178pernightsuite from$8,971$561pernightWas $4,109 – Save up to 66%Interior from $1,377($86pernight)4.1 rating out of 5 (2,262 reviews) -
11 Night Panama Canal Partial Transit: Mexico Costa Rica & Belize
Norwegian Jewel - OPEN BAR!
Departing from: Miami, FloridaPorts of Call:- George Town, Grand Cayman
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- Harvest Caye, Belize
- Cozumel, Mexico
Sailing Dates:- December 2025
- January 2026
- March 2026
interior from$1,341$122pernightoceanview from$1,521$138pernightbalcony from$2,581$235pernightsuite from$2,821$256pernightRewards & Bonus Offers:Interior from $1,341($122pernight)3.7 rating out of 5 (2,418 reviews) -
12 Night Panama Canal with Costa Rica & Caribbean
Caribbean Princess
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- George Town, Grand Cayman
- Falmouth, Jamaica
- Puerto Limon, Costa Rica
- Panama Canal (Partial Transit)
- Colon, Panama
- Oranjestad, Aruba
- Willemstad, Curacao
Sailing Dates:- November 2025
- February 2026
interior from$1,448$121pernightoceanview from$1,528$127pernightbalcony from$2,078$173pernightsuite from$2,468$206pernightRewards & Bonus Offers:Interior from $1,448($121pernight)3.9 rating out of 5 (1,914 reviews) -
16 Night Panama Canal - Ocean to Ocean
Caribbean Princess
Departing from: San Pedro (Los Angeles), CaliforniaPorts of Call:- Puerto Vallarta, Mexico
- Huatulco, Mexico
- Puerto Chiapas (Tapachula), Mexico
- Puntarenas, Costa Rica
- Panama City (Fuerte Amador), Panama
- Panama Canal Full Transit
- Oranjestad, Aruba
- Ft. Lauderdale (Port Everglades), Florida
Sailing Dates:- September 2025
interior from$1,528$96pernightoceanview from$1,708$107pernightbalcony from$2,228$139pernightsuite from$3,358$210pernightRewards & Bonus Offers:Interior from $1,528($96pernight)3.9 rating out of 5 (1,914 reviews) -
13 Night Panama Canal Eastward
Serenade of the Seas
Departing from: San Diego, CaliforniaPorts of Call:- Puerto Vallarta, Mexico
- Huatulco, Mexico
- Puntarenas, Costa Rica
- Panama Canal Full Transit
- Cartagena, Colombia
- Miami, Florida
Sailing Dates:- September 2025
interior from$1,538$118pernightoceanview from$1,956$150pernightbalcony fromCall for availabilitysuite fromCall for availabilityWas $3,028 – Save up to 49%Interior from $1,538($118pernight)4.1 rating out of 5 (1,829 reviews) -
15 Night Panama Canal: Mexico Costa Rica & Colombia
Norwegian Joy - OPEN BAR!
Departing from: San Pedro (Los Angeles), CaliforniaPorts of Call:- Cabo San Lucas, Mexico
- Acapulco, Mexico
- Puerto Quetzal, Guatemala
- Puerto Caldera (Puntarenas), Costa Rica
- Panama City, Panama
- Panama Canal Full Transit
- Cartagena, Colombia
- Miami, Florida
Sailing Dates:- October 2025
interior from$1,646$110pernightoceanview from$2,096$140pernightbalcony from$2,796$186pernightsuite from$2,896$193pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Earn 10 points per $1 spent
- Exclusive: Up to $200 Bonus to Spend on Board - Call
- BOGO - Second Guest Flies Free
- Exclusive - Free $50 Shore Excursion Coupon
- Save up to $150 Instantly! Call and Mention: CruiseFirst
- Up to $1,500 Off All Cruises + Enhanced More at Sea Perks
Interior from $1,646($110pernight)4.2 rating out of 5 (988 reviews) -
11 Night Panama Canal: Mexico Costa Rica & Belize
Norwegian Pearl - OPEN BAR!
Departing from: Miami, FloridaPorts of Call:- Ocho Rios, Jamaica
- Cartagena, Colombia
- Cruise Gatun Lake And Panama Canal
- Colon, Panama
- Puerto Limon, Costa Rica
- Harvest Caye, Belize
- Cozumel, Mexico
Sailing Dates:- December 2025
- January 2026
interior from$1,686$153pernightoceanview from$2,036$185pernightbalcony from$3,136$285pernightsuite from$3,236$294pernightRewards & Bonus Offers:Interior from $1,686($153pernight)3.8 rating out of 5 (2,064 reviews) -
12 Night Panama Canal Holiday: Costa Rica & Greater Antilles
Rotterdam
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Relaxaway, Half Moon Cay, Bahamas (Cruiseline Private Island)
- Willemstad, Curacao
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- Ocho Rios, Jamaica
Sailing Dates:- December 2025
interior from$1,819$152pernightoceanview from$2,319$193pernightbalcony from$2,619$218pernightsuite from$4,019$335pernightRewards & Bonus Offers:- Cruises.com Rewards = Free Cash! Earn 10 points per $1 spent
- Exclusive - Free $50 Shore Excursion Coupon
- Limited-Time: Kids Sail Free!
- Up to $500 to Spend on Board, Kids Sail Free & More
- Free Drinks, Dining, and Excursions with Select Fares
- No Interest or Approval: Book with No Cruise Payment Due Today
- Call for rates too low to show!
Interior from $1,819($152pernight)4.4 rating out of 5 (281 reviews) -
12 Night Panama Canal with Costa Rica & Caribbean Holiday
Caribbean Princess
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Oranjestad, Aruba
- Willemstad, Curacao
- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Puerto Limon, Costa Rica
- George Town, Grand Cayman
Sailing Dates:- December 2025
interior from$1,928$161pernightoceanview from$2,168$181pernightbalcony from$3,138$262pernightsuite from$3,798$317pernightRewards & Bonus Offers:Interior from $1,928($161pernight)3.9 rating out of 5 (1,914 reviews) -
11 Night Panama Canal & Southern Caribbean
Celebrity Ascent
Departing from: Ft. Lauderdale (Port Everglades), FloridaPorts of Call:- Cartagena, Colombia
- Panama Canal (Partial Transit)
- Colon, Panama
- Oranjestad, Aruba
- Willemstad, Curacao
- Kralendijk, Bonaire
Sailing Dates:- March 2026
interior from$2,064$188pernightoceanview from$2,729$248pernightbalcony from$3,604$328pernightsuite from$40,068$3,643pernightWas $5,900 – Save up to 65%Interior from $2,064($188pernight)4.6 rating out of 5 (93 reviews) -
15 Night Panama Canal - Westbound
Radiance of the Seas
Departing from: Tampa, FloridaPorts of Call:- George Town, Grand Cayman
- Cartagena, Colombia
- Colon, Panama
- Panama Canal Full Transit
- Puerto Quetzal, Guatemala
- Puerto Vallarta, Mexico
- Los Angeles, California
Sailing Dates:- April 2025
interior from$2,365$158pernightoceanview from$3,513$234pernightbalcony from$8,733$582pernightsuite fromCall for availabilityRewards & Bonus Offers:Interior from $2,365($158pernight)4.2 rating out of 5 (1,291 reviews)
Discount Panama Canal Cruises
Search Panama Canal Cruises
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